Bukayo Saka and Gabriel Magalhaes with Gabriel Martinelli all missed Arsenal first training session after the national team break.
Football London understands that Saka has withdrawn from the English camp due to muscle problems.
In addition to the three wounded who returned from their respective national camps Jurrien Timber also disappeared from training.
Arsenal host Manchester City in the title race this weekend.
The Gunners need the best players to be fully fit before that to continue their lead at the top of the Premier League.
